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Submit [Clinical Trials](https://pendulumlife.com/pages/research-clinical-trials) [Our Health Surveys](https://pendulumlife.com/pages/health-surveys) [Participate in Research](https://pendulumlife.com/pages/participate-research) [Conduct Research with Pendulum](https://pendulumlife.com/pages/become-a-research-collaborator) ## Scientific research is our foundation ## Scientific research is our foundation Scientific Discoveries Breakthroughs are put to the test with clinical trials Human Advancement Through rigorous trial protocols, our knowledge grows Groundbreaking Innovation Results help us create effective products that improve your health ## Participate in breakthrough research Clinical trials are integral to developing new approaches to medicine. Through collaboration with leading academic research institutions, top investigators, and passionate human beings all over the world, we grow our understanding of the microbiome and unravel its connection to your health — together. [Explore our studies](https://pendulumlife.com/pages/clinical-trial#nav-clinical-trial) ## Clinical Trials All Trials ## PRO-PLATINUM: A Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy of a Probiotic Intervention on the Gut and Vaginal Microbiome of Ovarian Cancer Patients Undergoing Treatment with Platinum Chemotherapy Duration:6 chemotherapy cycles (about 6 months) Eligibility:Ovarian cancer patients undergoing chemotherapy Status:Now enrolling Conducted by:The Ohio State University Wexner Medical Center [Enroll now](https://www.clinicaltrials.gov/study/NCT07144826) Principal Investigator:Laura Chambers, DO Design:Double-blind, placebo-controlled study Date of completion:Estimated 2026 ClinicalTrials.gov Identifier:[NCT07144826](https://www.clinicaltrials.gov/study/NCT07144826) The study:This study investigates the efficacy of a probiotic intervention in altering the gut microbiome of 124 women with advanced (stage II, III or IV) or recurrent platinum-sensitive ovarian cancer who are receiving platinum-based chemotherapy (cisplatin or carboplatin-containing regimens). Goal:To evaluate changes in gut microbiome composition in ovarian cancer patients randomized to a probiotic intervention versus placebo during platinum chemotherapy. Show more Show less Pendulum Metabolic Daily ## Fecal Microbiota Transplantation for Auto-Brewery Syndrome Duration:9 months Eligibility:Adults with diagnosis of Auto-Brewery Syndrome (ABS) and documented ABS symptoms for at least one year, including supervised ethanol testing or a positive glucose challenge test in a supervised setting. Status:Now enrolling Conducted by:Massachusetts General Hospital [Enroll now](https://clinicaltrials.gov/study/NCT06083142) Principal Investigator:Elizabeth L. Hohmann, MD Estimated enrollment:8 adults Design:Open-label pilot study Date of completion:Estimated 2026 ClinicalTrials.gov Identifier:[NCT06083142](https://clinicaltrials.gov/study/NCT06083142) The study:This Phase 1 clinical trial, funded by the National Institute of Health (NIH), will explore the safety and tolerability of Fecal Microbiota Transplantation (FMT) in 8 patients with ABS. Goal:The goal of this study is to assess the safety and feasibility of antibiotic “clean out” pretreatment, microbial restoration via capsule FMT, and daily administration of potato starch and Pendulum Metabolic Daily for 9 months to manage Auto-Brewery Syndrome. Additionally, the goal will be to understand how the treatment affects breathalyzer blood alcohol levels and whether the gut bacteria in patients with ABS can durably be impacted. Show more Show less Pendulum Glucose Control ## Phase 2 Trial of 5-Strain Probiotic Formulation in Hormone Receptor-Positive Breast Cancer Receiving Aromatase Inhibitor to Prevent Bone Loss Duration:18 months (including baseline, intervention, and follow-up) Eligibility:Women with early-stage hormone receptor-positive breast cancer initiating aromatase inhibitor therapy Status:Now enrolling Conducted by:Mayo Clinic in Florida [Enroll now](https://clinicaltrials.gov/study/NCT07044310) Estimated enrollment:30 women.
Cohort 1: 20 Postmenopausal women
& Cohort 2: 10 Premenopausal or perimenopausal women on ovarian function suppression Design:Phase II, open-label, interventional study Date of completion:Estimated 2026 ClinicalTrials.gov Identifier:[NCT07044310](https://clinicaltrials.gov/study/NCT07044310) The study:This investigator-initiated clinical trial evaluates the effects of Pendulum Glucose Control in preventing bone loss among women with early-stage hormone receptor-positive breast cancer starting aromatase inhibitor therapy. Aromatase inhibitors are commonly used in breast cancer treatment, but are known to adversely affect bone health, body weight, blood glucose levels, and waist circumference. Participants will receive Pendulum Glucose Control for 12 months, beginning three months after initiating aromatase inhibitor therapy. Assessments will include blood samples, bone mineral density (BMD) testing, and patient-reported outcomes. Follow-up will continue for 3 months after treatment concludes. Goal:To assess the efficacy of Pendulum Glucose Control in mitigating aromatase inhibitor-associated bone loss, as measured by changes in C-terminal telopeptide of type 1 collagen (CTx) levels and bone mineral density. Secondary goals include evaluating safety, metabolic biomarkers, changes in body weight and waist circumference, cytokine profiles, gut microbiome associations, and aromatase inhibitor-related musculoskeletal symptoms. Show more Show less ## A Two-Phase Study on the Safety and Tolerance of a Novel Probiotic in Healthy Adults: Open-Label and Double-Blind, Placebo-Controlled Study Duration:2 months Eligibility:Healthy adults, aged between 18-65 years old Status:Active, Fully Enrolled Conducted by:Pendulum Therapeutics Estimated enrollment:Phase 1: 30 people \| Phase 2: 60 people Design:Phase 1: Open-Label Study \| Phase 2: Randomised Double-Blind, Placebo-Controlled Study Date of completion:Estimated 2025 The study:Pendulum Therapeutics is conducting a Two-Phase Study on the Safety and Tolerance of a Pendulum Probiotic. The first phase will look at two different doses of the probiotic and it’s impact on food cravings and GLP-1 plasma levels. Results from the open-label phase one study will guide dose information for the Phase Two double blinded, placebo controlled study. Goal:Evaluate the impacts of daily consumption of Pendulum Probiotic on measures of food cravings and plasma GLP-1 levels. Show more Show less ## Supplementation with a next-generation synbiotic in individuals who are overweight or with obesity: a triple-blinded, randomized, controlled clinical trial Duration:3 months Eligibility:Adults ages 18-50, BMI: 25-40 without a diabetes diagnosis Status:Completed Conducted by:Texas Christian University [Study details](https://clinicaltrials.gov/study/NCT06213480) Estimated enrollment:60 participants Design:Triple-blinded, randomized, placebo-controlled Date of completion:Estimated April 2025 ClinicalTrials.gov Identifier:[NCT06213480](https://clinicaltrials.gov/study/NCT06213480) The study:Texas Christian University is recruiting participants ages 18-50 that have a BMI between 25-40 and do not have diabetes diagnosis to join a 3-month study of Pendulum Probiotic and measures of body composition, metabolic health, mood and eating behavior. Goal:Evaluate impacts of daily consumption of Pendulum Glucose Control on measures of body composition, metabolic health, mood, and food behavior. Show more Show less ## A Randomized, Double-Blind, Placebo-Controlled Study of Probiotics As Adjuvant Therapy for Bipolar Depression: A Proof-of-Concept Trial Duration:12 weeks Eligibility:Adults with a medical diagnosis of bipolar disease (type I or II) receiving approved treatments for bipolar depression for at least 4 weeks Status:Completed Conducted by:University of São Paulo, Brazil (FMSUP) [Study details](https://clinicaltrials.gov/study/NCT05762887) Estimated enrollment:84 participants Design:Randomized, double-blind, placebo-controlled trial Date of completion:January 2025 ClinicalTrials.gov Identifier:[NCT06213480](https://clinicaltrials.gov/study/NCT05762887) The study:University of São Paulo Bipolar Research Program is recruiting adults with bipolar (type I & II) presenting with subclinical depressive symptoms or a major depressive episode to participate in an outpatient randomized, double-blind, placebo-controlled trial that will last 12 weeks. Goal:In a proof-of-concept study, evaluate the antidepressant efficacy of adjunctive administration of probiotics in participants with bipolar depression and evaluate potential inflammatory and metabolic markers associated with response to treatment. Show more Show less Akkermanisa and akkermansia 500 pro ## Detection of Akkermansia muciniphila utilizing serial longitudinal samples with the BiomeSense GutLabTM: an open-label proof of concept study Duration:4 months Eligibility:Adults, ages 18-75, and in general good health, local to the San Francisco Bay Area or Chicago, IL Status:Completed Conducted by:Pendulum Therapeutics, BiomeSense [Press release](https://www.eurekalert.org/news-releases/1055573) Estimated enrollment:10 participants + household controls Design:Open-label Date of completion:November 2024 The study:Pendulum Therapeutics in partnership with BiomeSense are conducting a 4-month study of Pendulum Akkermansia measuring the serial longitudinal detection of the probiotic strain using BiomeSense GutLabTM technology. Goal:Evaluate serial longitudinal detection of Akkermansia and Akkermansia 500 PRO in stool samples of healthy individuals over an 8-week supplementation period. Show more Show less ## OsteoPreP Study: Evaluating how Pendulum probiotics can support bone health in early postmenopausal women Duration:12 months Eligibility:Postmenopausal women, 40-65 years Status:Completed Conducted by:Australian Catholic University, Pendulum Therapeutics [Study details](https://clinicaltrials.gov/ct2/show/NCT05348694) Estimated enrollment:160 participants Design:Double-blinded, randomized, placebo controlled Date of completion:Estimated May 2025 ClinicalTrials.gov Identifier:[NCT05348694](https://clinicaltrials.gov/ct2/show/NCT05348694) The study:Studies indicate a potential link between the gut microbiome and bone health. Australian Catholic University is recruiting female participants within 1 to 4 years of their final menses to join this 12-month study of Pendulum Probiotic and bone health. Goal:To measure the impacts of long-term probiotic supplementation in early postmenopausal women on bone, muscle and metabolic health. [Press Release: Researchers look at whether probiotics can slow osteoporosis in early menopause](https://pendulumlife.com/blogs/news/researchers-look-at-whether-probiotics-can-slow-osteoporosis-in-early-menopause) Show more Show less PENDULUM GLUCOSE CONTROL ## Evaluating the safety and metabolic effects of Pendulum probiotics on glucose control associated with Type 2 diabetes Duration:3 months Eligibility:Type 2 diabetes, metformin, 18-75 years Status:Completed Conducted by:Pendulum Therapeutics Estimated enrollment:76 participants Design:Double-blinded, randomized, placebo controlled Date of completion:September 2018 ClinicalTrials.gov Identifier:[NCT03893422](https://clinicaltrials.gov/ct2/show/NCT03893422) The study:12-week double-blind, randomized placebo-controlled, proof of concept study, evaluating the safety and metabolic effects of Pendulum probiotics in the overall dietary management of Type 2 diabetes. Goal:To evaluate the safety and metabolic effects of Pendulum probiotics on glucose control associated with Type 2 diabetes. Results:Study participants that were administered Pendulum Glucose Control had statistically and clinically significant improvements. In individuals with Type 2 diabetes on Metformin, A1c levels were reduced by 0.6% and postprandial glucose spikes (Area Under the Curve or AUC) were reduced by 33%, as compared to placebo. Pendulum Glucose Control was safe and well-tolerated by study participants. [Press Release: First-Ever Medical Probiotic That Provides The Dietary Management Of A1C And Blood Glucose Levels](https://pendulumlife.com/blogs/news/pendulum-therapeutics-announces-publication-of-clinical-data-for-first-ever-medical-probiotic-that-provides-the-dietary-management-of-healthy-a1c-and-blood-glucose-levels) Scientific Publication: BMJ Open Diabetes Research & Care](https://drc.bmj.com/content/8/1/e001319) Show more Show less PENDULUM GLUCOSE CONTROL ## Proof of concept study, evaluating Pendulum probiotics use in conjunction with continuous glucose monitoring smartphone app measurements Duration:6 weeks Eligibility:18-75 years Status:Completed Conducted by:Pendulum Therapeutics Estimated enrollment:6 participants Design:Double-blinded, randomized, placebo controlled, cross-over proof of concept study Date of completion:June 2018 ClinicalTrials.gov Identifier:[NCT04424888](https://clinicaltrials.gov/ct2/show/NCT04424888) The study:Self-administered meal-tolerance tests conducted to assess the impact of Pendulum Glucose Control on glucose levels through continuous glucose monitoring smart phone app measurements. Goal:Proof-of-concept study to investigate the potential of collecting robust, real-time clinical study measures of glucose levels without clinic visits. Results:Participants reported general satisfaction with sensor management, Pendulum Glucose Control, and the smartphone app. Despite a lack of sufficient power to achieve statistical significance, meaningful changes in the postprandial glucose response in real-world settings were detected, meriting larger studies in the future. [Press Release: Continuous Glucose Monitors Could Modernize Clinical Trials with Remote Data Collection](https://pendulumlife.com/blogs/news/continuous-glucose-monitors-could-modernize-clinical-trials-with-remote-data-collection) Scientific Publication: JMIR Formative Research](https://formative.jmir.org/2021/3/e20175) Show more Show less Duration:6 chemotherapy cycles (about 6 months) Eligibility:Ovarian cancer patients undergoing chemotherapy Status:Now enrolling Conducted by:The Ohio State University Wexner Medical Center [Enroll now](https://www.clinicaltrials.gov/study/NCT07144826) Principal Investigator:Laura Chambers, DO Design:Double-blind, placebo-controlled study Date of completion:Estimated 2026 ClinicalTrials.gov Identifier:[NCT07144826](https://www.clinicaltrials.gov/study/NCT07144826) Show more Show less Pendulum Metabolic Daily ## Fecal Microbiota Transplantation for Auto-Brewery Syndrome Duration:9 months Status:Now enrolling Conducted by:Massachusetts General Hospital [Enroll now](https://clinicaltrials.gov/study/NCT06083142) Principal Investigator:Elizabeth L. Hohmann, MD Estimated enrollment:8 adults Design:Open-label pilot study Date of completion:Estimated 2026 ClinicalTrials.gov Identifier:[NCT06083142](https://clinicaltrials.gov/study/NCT06083142) Show more Show less Pendulum Glucose Control ## Phase 2 Trial of 5-Strain Probiotic Formulation in Hormone Receptor-Positive Breast Cancer Receiving Aromatase Inhibitor to Prevent Bone Loss Duration:18 months (including baseline, intervention, and follow-up) Eligibility:Women with early-stage hormone receptor-positive breast cancer initiating aromatase inhibitor therapy Status:Now enrolling Conducted by:Mayo Clinic in Florida [Enroll now](https://clinicaltrials.gov/study/NCT07044310) Estimated enrollment:30 women.
Cohort 1: 20 Postmenopausal women
& Cohort 2: 10 Premenopausal or perimenopausal women on ovarian function suppression Design:Phase II, open-label, interventional study Date of completion:Estimated 2026 ClinicalTrials.gov Identifier:[NCT07044310](https://clinicaltrials.gov/study/NCT07044310) Show more Show less 1234 ## Become a microbiome pioneer If you're interested in participating in our research, sign up and we'll send you information about upcoming programs and eligibility requirements. You do not need to be a Pendulum customer to be considered. [Learn more](https://pendulumlife.com/pages/participate-research) [Learn more](https://pendulumlife.com/pages/participate-research) FSA/HSA eligible with × ## FSA/HSA eligible with This product may be eligible for purchase with your FSA/HSA funds. Get up to 100% reimbursed using your pre-tax dollars with Burst. 1. 1 ### Purchase with any payment method Use your credit card, debit card, or other payment method at checkout. 2. 2 ### Get a letter of medical necessity After checkout, fill out a brief health questionnaire for our licensed providers to review. 3. 3 ### Get your reimbursement If approved, Burst will help you get reimbursed from your FSA/HSA account. Continue shopping pendulumlife.com # pendulumlife.com is blocked This page has been blocked by an extension - Try disabling your extensions. ERR\_BLOCKED\_BY\_CLIENT Reload This page has been blocked by an extension pendulumlife.com # pendulumlife.com is blocked This page has been blocked by an extension - Try disabling your extensions. ERR\_BLOCKED\_BY\_CLIENT Reload This page has been blocked by an extension pendulumlife.com # pendulumlife.com is blocked This page has been blocked by an extension - Try disabling your extensions. ERR\_BLOCKED\_BY\_CLIENT Reload This page has been blocked by an extension pendulumlife.com # pendulumlife.com is blocked This page has been blocked by an extension - Try disabling your extensions. ERR\_BLOCKED\_BY\_CLIENT Reload This page has been blocked by an extension pendulumlife.com # pendulumlife.com is blocked This page has been blocked by an extension - Try disabling your extensions. ERR\_BLOCKED\_BY\_CLIENT Reload This page has been blocked by an extension pendulumlife.com # pendulumlife.com is blocked This page has been blocked by an extension - Try disabling your extensions. ERR\_BLOCKED\_BY\_CLIENT Reload This page has been blocked by an extension pendulumlife.com # pendulumlife.com is blocked This page has been blocked by an extension - Try disabling your extensions. ERR\_BLOCKED\_BY\_CLIENT Reload This page has been blocked by an extension pendulumlife.com # pendulumlife.com is blocked This page has been blocked by an extension - Try disabling your extensions. ERR\_BLOCKED\_BY\_CLIENT Reload This page has been blocked by an extension shop.app # shop.app is blocked This page has been blocked by an extension - Try disabling your extensions. ERR\_BLOCKED\_BY\_CLIENT Reload This page has been blocked by an extension Earn Rewards Refer Friends